Candidate City Statement for WCN 2023: Montréal

Montréal tops the rankings of host cities in the Americas for most international conferences1. Its attractions and qualities have made it a go-to location for business and leisure travellers. As one of the largest hubs for neuroscience in Canada—240 neuroscience professionals and over 40 companies related to neuroscience, Montréal is a first-rate destination for all with a passion for innovation, understanding the brain and treating patients with neurological disorders.

Together with the Canadian Neurological Society (CNS), generous funding for travel grants by the city’s convention community will enable a record number of scholars and fellows from emerging economies, such as Latin America and Africa, to attend this major event.

In order to foster innovative care and research on a global scale, The Neuro—McGill University’s Montreal Neurological Institute and Hospital—will make its open data platforms available to the members of the WFN and help identify potential Canadian collaborators. Founded by Dr. Wilder Penfield, The Neuro is a world leader in the field and has a rich history of welcoming the international neuroscientific community—trainees, researchers and clinicians alike. A pioneer, The Neuro is the first Open Science institute in the world, helping accelerate new therapy research and solutions.

The WCN 2023 will also be an opportunity to expand the annual grants and awards program the CNS jointly administers with the World Federation of Neurology. A new program being developed will focus on colleagues from Sub-Saharan Africa.

Montréal is a smart choice for WCN 2023. Recognized as Canada’s research and higher education capital, the city has 1,500 institutions active in R&D, 200 research centres, 11 higher learning institutions including four major universities, and two academic health centres—neurology from pediatric to adult, from general to highly specialized—making it a high-tech, artificial intelligence, health and life sciences hub. Among the Top 20 safest big cities in Canada and the United States2, Montréal also enjoys one of the most vibrant urban scenes, thanks to its numerous world-class festivals, international cuisine, legendary hospitality and European flair. It is home to a richly multicultural community where 100 languages are spoken. Easily accessible and practical, it is only 20 minutes from the airport, which services 150 direct flights from North Africa, the Middle East, Asia, Latin America, Europe, and North America. The wide range of downtown accommodations includes 16,000 hotel rooms within a 10-minute walk from the city’s convention centre, 4,000 of which are directly linked to the centre. Its proximity to 90 million Northeastern Americans less than a two-hour flight away, or within driving distance, means even more students, young researchers, and clinicians can attend the congress. Participants will be able to partake in technical tours of The Neuro and several other university and hospital sites during their stay in Montréal. Success, innovation, and expertise await you in Montréal. October is when the city really shows its true autumn colours.

References

  1. Union of International Associations 2017/2018
  2. FBI & Statistics Canada 2018

Letter from the editors

Steven L. Lewis, MD

Walter Struhal, MD

We would like to welcome all neurologists to the July-August 2019 issue of World Neurology, the official newsletter of the World Federation of Neurology (WFN). This issue includes three well illustrated articles from around the globe reporting from each country’s involvement and activities surrounding World Brain Day 2019, including reports from Turkey, Pakistan, and the report from Cameroon where the World Brain Day theme (Migraine: The Painful Truth) is also used as a thoughtful analogy to the author’s view of the current situation in the country.

In the President’s column, WFN President Prof. William Carroll updates us on important issues at hand to be decided at this year’s Council of Delegates (COD) meeting that will be held during the upcoming XXIV World Congress of Neurology (WCN) Oct. 26 in Dubai. Regarding these important issues to be decided at the COD, this issue features the statements from the three cities/countries vying for the site of WCN 2023, to be held within the Americas (in alphabetical order by city): Mexico City, Mexico; Montreal, Canada; and Rio de Janeiro, Brazil. Statements from the candidates for WFN Treasurer and Elected Trustee also appear in this issue.

In the History column, Prof. Peter Koehler discusses two important 17th century figures in the history of the science of the brain who provided critical insights beyond that that had been well accepted at the time.

This issue also features a thank-you note from a neurologist from Nigeria to his teachers from Austria who dedicated their time to provide him with the benefit of their experience and skills in nerve conduction studies and electromyography.

Finally, we look forward to seeing many of you at the upcoming WCN Oct. 27-31, 2019 in Dubai. Please note the reminders in this issue for WFN member societies to field teams of four—with free registration—for this year’s sure-to-be-exciting Tournament of the Minds.

 

 

Migraine: The Painful Truth – World Brain Day 2019 in Pakistan

By Dr. Abdul Malik, MD, DCN, PGDN, MBA

The Neurology Awareness and Research Foundation (NARF) in Pakistan organized countrywide activities to mark the fifth Annual World Brain Day, with the theme Migraine: The Painful Truth. Migraine affects one in seven people and, together with other headache disorders, is one of the leading causes of disability worldwide.

Besides countrywide awareness activities in all four provinces across Pakistan, NARF organized the majority of its activities in the largest city of Karachi. Flyers about migraine were distributed for the general public in the family medicine clinics. NARF also prepared migraine signs/ symptoms/ treatment/ diet and lifestyle modifications awareness mounts, which were placed in 1,000 clinics across the country. A month-long Facebook campaign as well as Twitter activities were executed by placing video messages and awareness posts in local languages as well as the matter provided from the WFN. World Brain Day posters were placed in almost all the major institutes and departments of neurology in Pakistan.

On July 22, under the aegis of the World Federation of Neurology (WFN) in association with the International Headache Society (IHS), NARF celebrated the Fifth Annual World Brain Day with a free migraine clinic and press conference by the renowned neurologists of the country, including Prof. Mohammad Wasay, NARF president; Prof. Aziz Sonawala; former PHS president; and Profs. Arif D. Herakar and Dr. Abdul Malik from the Liaquat College of Medicine & Dentistry in Karachi. In the free migraine clinic, which was held at the Karachi Press Club, a large number of patients attended. They were provided free consultation as well as provided medications for the prophylactic treatment of migraine.

A unique activity was conducted for the awareness of migraine in collaboration with the students of the Masters for the Headache Disorders (MHD) from the University of Copenhagen and Danish Headache Center in Denmark. This activity was done under the patronage of the Prof. Rigmor Jenssen, course director. We had prepared and disseminated messages on migraine awareness provided by the WFN. This included almost 20 videos messages in 16 languages from 14 countries (Colombia, Denmark, Greece, Ireland, Italy, Latvia, Nigeria, Pakistan, Philippines, Slovenia, Spain, Sweden, the U.K., and the U.S.).

On July 31, 2019, a Continuing Medical Education (CME) activity on #migraine #thepainfultruth: Diagnosis & Management was held at Liaquat College of Medicine & Dentistry (LCMD) in context with #worldbrainday. Prof. M. Wasay, Prof. Aziz B. Sonawala, and Associate Prof. Dr. Abdul Malik were the speakers. Prof. Rizwan Azami, director of medical services DSH, and Dr. Rashid Naseem Khan, principal LCMD, were the guests of honor. A large number of undergraduate students, postgraduate trainees, and faculty members attended the interactive session.

The awareness activities were covered in national and local newspapers as well as in the electronic media. There were TV shows on migraine for public interest as well a question-and-answer session about migraine signs and symptoms and treatment. In the Urdu language, an article was published in a local magazine about the awareness of migraine.

In short, a comprehensive advocacy campaign for migraine awareness was executed on the occasion of this year’s World Brain Day 2019 in Pakistan, keeping in view that migraine is the most common neurologic disorder that is treatable.

Dr. Abdul Malik, MD, DCN, PGDN, MBA, is associate professor of neurology in Karachi, Pakistan.

 

 

WFN Treasurer: Richard Stark

It has been a great privilege to be treasurer of WFN since 2015. During this time, I have been delighted to see the finances of the federation become even stronger.

Richard Stark

WFN’s mission statement is: “… to foster quality neurology and brain health worldwide, a goal we seek to achieve by promoting global neurological education and training, with the emphasis placed firmly on underresourced parts of the world.”

I strongly support these aims, and my experience on the board of trustees for the past four years confirms that it is applied in practice.

The role of the treasurer is to advise the other trustees about the state of the finances, and thus which programs can be supported. For example, one of our current major programs involves supporting training in Africa and Latin America. The impact on the budget extends for some years into the future. We must be confident that our position is sound (and will remain so) in order to make the commitment to support training for up to four years in the future.

The income stream for WFN derives in part from member society fees and royalties from the Journal of Neurological Sciences (which are both relatively stable), and more substantially from the Congress (WCN), which is much more volatile. The 2015 meeting in Santiago significantly exceeded expectations, and the Kyoto meeting in 2017 was an outstanding financial success. As treasurer, I must thank all those involved in those meetings for working so hard to ensure success. Early projections for Dubai 2019 are positive also.

The financial success of WCN depends largely on the support from pharmaceutical companies, which depends, in turn, on the stage of commercial development of their products. These factors are outside our control. The management of the WFN’s finances, therefore, requires an astute and flexible approach, efficient administration, and conservative estimation of projected income streams.

My experience over the past four years has helped me to have a more indepth understanding of these issues and should be helpful to the WFN over the next four years. I believe, therefore, that I have something of substance to offer if elected.

I should set out some aspects of my background that have relevance to the position of treasurer of WFN. These include:

  • treasurer of the Sydney 2005 WCN, which was a huge financial success
  • treasurer of the Australian Association of Neurologists (1997-2003)

WCN 2005 took place at a time of substantial exchange rate volatility, and the strategies designed to minimize adverse impacts of this contributed to the financial success of the conference. Subsequent experience as treasurer of WFN over the past four years (with the impact of Brexit) has reinforced the necessity to have funds diversified in such a way as to minimize volatility while not excluding the possibility of organic growth.

The WFN has a strong tradition of efficient use of funds. This relies on the generous donation of time from the executive as well as the hard work of administrative staff. This efficiency must continue. If elected to a further term, I undertake to continue to work diligently with the executive to ensure that the financial management of the WFN allows it to pursue its aims and objectives.

 

 

World Brain Day in Turkey

By Prof. Serefnur Ozturk

The Turkish Neurological Society has been celebrating World Brain Day since 2014. Every year, we follow WFN guidelines and create public awareness by organizing meetings, public service announcements, and newsletters. This year, we partnered with İstanbul, Besiktas municipality, and organized a meeting about this year’s theme “Migraine: The Painful Truth.”

The meeting took place on July 22, World Brain Day, and was open to public attendance. Migraine is a common disorder in our population (reported as one of five women and one of 10 men). Banners were distributed throughout İstanbul promoting the meeting along with powerful support by social media and the national press.

We appreciate the WFN for supporting societies with toolboxes and webinars every year. We also encouraged our members to organize World Brain Day events, and this year, many meetings were held across Turkey. Furthermore, we collaborated with the International Headache Society to increase awareness for migraine.

Prof. Serefnur Ozturk is president of the Turkish Neurological Society.

Memoirs of Austria: Echos of Kindness

By Osigwe P. Agabi, MBBS (BENIN), MWACP, FMCP

Undertaking my residency training in neurology in Nigeria had its advantages. I got to learn and practice in a culture where my expertise would be deployed, and the diversity and sheer number of neurological cases and conditions enabled me to hone my clinical skills. The training also afforded me the privilege of providing answers (and some succor, I hope) to patients whose conditions had been undiagnosed or misdiagnosed, cursorily attributed to “spiritual” forces in the absence of a logical alternative explanation. This was enabled by the increase in availability of some technologies, including brain imaging and support laboratory diagnostics for those who could afford them.

Despite these, however, one gaping void was the absence of expertise and technology for electromyography and nerve conduction study (EMG/NCS) testing. Four decades prior was the last time my training center had functioning EMG/NCS, and the combination of competing financial commitments and lack of expertise ensured this was not revived.

That was until early 2018, when a good natured alumnus donated EMG equipment and conducted a preliminary workshop that whet my appetite. About the same time, serendipity brought my mentors together at the EAN regional teaching course in Ouagadougou, and discussions ensued that culminated in the opportunity to begin my formal training in EMG/NCS in Austria.

As I sat down on the Lufthansa flight bound to Vienna from Lagos, Nigeria, my thoughts wandered. What would Austria be like? What will this experience be? Will I achieve my objectives? Will the weather be kind? Will I have problems communicating, as I speak no German?

I reached for my phone and looked down at the pictures of Profs. Walter Struhal and Wolfgang Grisold I had downloaded before the journey. It was this duo of renowned neurologists who had graciously agreed to offer themselves to train me in nerve conduction studies and electromyography at no cost that informed this journey. I thought about my family and the neurology unit back at the Lagos University Teaching Hospital in Nigeria. I thought most especially about my teacher, mentor, and boss, Prof. Njideka Okubadejo who had given her all to the actualization of this dream and how lucky I was to have her. I was still in this train of thought when I was jolted into consciousness by the air hostess who was waiting to take my order of refreshment.

I arrived in Vienna and headed straight for the University Hospital in Tullin where Prof. Struhal is head of neurology. Prof. Struhal is a kind gentleman with a calm disposition. I was taken to my apartment that contained most of what I was going to require for the period of my stay.

The next day, I was formally introduced to the neurology department and completed some administrative formalities. Every morning, there was a presentation of all patients, new and old, by the consultants with their relevant investigations and neuroimaging. I looked forward to this exercise every morning not only for its robust intellectual nature but also for the demonstration of genuine patient empathy. I was received warmly by all. I observed the team spirit, astute dedication to duties of all, both young and old.

The synergy between doctors, nurses, and other support staff was exemplary. I worked closely with Drs. Andreas Seiser and Brigit Riemer who were the neurologists in charge of neurophysiology. They walked me through the rudiments of NCS and EMG. They loved to teach and made the process seamless. I cannot forget the patients who offered themselves freely to this exercise so I could learn. I was glad to observe sessions of transcranial magnetic stimulation, fiber-optic endoscopic evaluation of swallowing, and some autonomic nerve testing, among others.

Twice every week, I commuted by train to Vienna to catch up with Prof. Grisold in his private practice. In his office, he laid bare nerve conduction and electromyography. He taught with uncommon dedication and passion, making sure I had an untainted understanding of the concepts. He taught me many secrets that only years of practice could bring. He had sessions with me as the patient. It is a great privilege to have been tutored by him. I will forever remain grateful.

Prof. Grisold wanted me to broaden my horizons on my many spheres of neurology. He reached out to many of his colleagues, including Dr. Stefan Meng, a radiologist with expertise in nerve and muscle ultrasonograpy. Dr. Meng was warm and highly knowledgeable, yet humble. He had some teaching sessions with me at the KFJ hospital in Vienna. Before this experience, nerve and muscle ultrasonography was a distant reality for me.

I also had the rare privilege of visiting Prof. Michaela Auer-Grumbach, a renowned neurogeneticist who added the icing on the cake for me. Before long, my 32-day visit had come to an end.

I am overwhelmed by the unconditional kindness, efforts, and support of Profs. Struhal and Grisold for bringing this dream to reality. This experience has awakened in me a restlessness to develop that which I have acquired and to impart to others after me. Yes, St. Augustine was right when he opined that “the world is a book, and those who do not travel read only one page.”

Osigwe P. Agabi, MBBS (BENIN), MWACP, FMCP, is a consultant physician and neurologist in the neurology unit of Lagos University Teaching Hospital in Nigeria.

 

 

Statement for Elected Trustee

It has been a tremendous privilege serving as elected trustee of the World Federation of Neurology (WFN). In my current roles as WFN trustee, chair of the WFN Education Committee, and editor of World Neurology, I am indebted to this organization and the opportunities it has provided me to help achieve its mission to foster quality neurology and brain health worldwide via the promotion of global neurologic education and training.

Steven L. Lewis, MD

My initial involvement with the WFN occurred coincident with my appointment by the American Academy of Neurology (AAN) as editor-in-chief of Continuum. This joint program of the WFN and the AAN (and its publisher Wolters Kluwer) provides print and online access to Continuum to user groups from more than 40 neurological societies from low- and lower-middle income countries. I have appreciated being involved as our two organizations work closely together to provide this resource for participants who would otherwise be unable to obtain it, including recent and ongoing collaborative efforts to improve and enhance this important global educational program.

As WFN trustee and as chair of the WFN Education Committee for the last six years, I have become integrated into the critical workings of this organization in education, training, and practice of neurology around the globe. I have learned so much from our talented staff, my esteemed colleagues on the many WFN committees and related organizations, and all of the co-trustees up to the president(s) whom I have been so privileged to work with. Their knowledge and expertise have been invaluable in my continued personal development and improving my effectiveness to our organization. In my additional role as World Neurology editor, I have had the privilege to help report on news about neurology and neurologists worldwide, a role that I cherish continuing as well as honing.

In my roles and experiences with the WFN, I have continued to meet so many remarkably talented neurologists worldwide. I continue to be impressed by the similarities among us all, despite differences in resources and access to care within and between regions. If re-elected as trustee, I look forward to continuing to help the WFN achieve its mission via continued partnership with national, regional, and international neurologic societies and disease-based organizations, and the WHO; optimizing our current regional teaching centers for neurologic training—now four African training centers and one in the Americas, with plans for other region(s) as well; growing our department visit programs, which have recently included wonderful partnerships with many European countries for African trainees, and one in the Americas for South American trainees; increasing awareness of travel and research grants for young neurologists from low- and lower-middle income countries; and continuing to react quickly to novel regional or global neurological issues or threats as they arise.

I would be honored to be re-elected as WFN trustee, and if so, I pledge to continue to faithfully serve our delegates and member neurologists for the mutual goal of improved neurological access and the highest quality of neurology and neurological health worldwide.

Critical Minds on the Brain in the 17th Century

By Peter J. Koehler

A number of medical students of human and animal bodies in the 17th century demonstrated a critical attitude toward the knowledge that was taught in books and by their teachers. Although inspired by the new mechanistic or iatrophysical physiology of René Descartes (1596-1650), they not only questioned the anatomical and physiological views of previous generations of anatomists and physicians (including Thomas Willis), but also Descartes’ own ideas. In this essay, I will discuss two of these critical young men.

Steno (by Justus Sustermans; public domain).

Danish Student Discovering a Duct

One was born and raised in Copenhagen, Denmark, where one of his teachers, the physician Thomas Bartholin (1616-1680) advised him to go to Holland, in particular Amsterdam. Armed with a letter of recommendation from Bartholin, the young man was welcomed by Gerard Blaes (Blasius, 1627-1682) who gave him lodging, a frequent custom at the time, and taught him anatomy.

Title page of Descartes’ De Homine (1662).

The relationship was soon disturbed, when the young man discovered a new anatomical structure in the head of a sheep, notably the duct of the parotid salivary gland that became eponymously related with his name: Niels Stensen (Steno, 1638-1686). His teacher Blaes, at several occasions, tried to turn the discovery to his own advantage. A few months later, Stensen continued his studies at Leiden University, where he was taught by Johannes van Horne (1621-1670) and Frans deleBoë (Sylvius, 1614-1672); his name is remembered in the term Sylvian fissure, both considered modern professors, stimulating practical research, in contrast to the men of learning, who kept to the old philosophy of Aristoteles.

Although the new philosophy of Descartes, who had stayed in the Netherlands for a large part of his career, had inspired him as well as many other scholars, and his world view incited study of the individual phenomena, Stensen found that many of his ideas were speculative. Mathematician/physicist and astronomer Christiaan Huygens (1629-1695), for instance, found that mechanical laws, upon which Descartes founded his physics, were not correct. Descartes obviously had put into perspective the significance of observation as the senses were fallible, but this seemed to be truth also for the power of reason.

The criticism increased by the posthumous publication of Descartes’ book on the functions of the human body, Tractatus de Homine (1662). Descartes had written the discourse already in 1632, but did not publish it, fearing the inquisition (as Galilei had experienced in Italy, 1632). Descartes had written his discourse to show that the function of the human body could be comprehended in mechanistic terms, controlled by the brain by means of the nervous system.

Swammerdam’s nerve-muscle preparation from the posthumously published Bybel der natuure of historie der insecten [Bible of nature or history of insects] (1737).

Dutch Student Making a Nerve-Muscle Preparation

This inspired Stensen. He decided to study the structure and physiology of the brain. He soon found that the old idea of spirits conducted by nerves to control the muscles, an old Galenic concept, was difficult to prove. Around the same time, another Leiden medical student worked on the same problem. Son of an Amsterdam pharmacist, he started his medical studies in Leiden in 1661, doing research on respiration with Frans deleBoë. The old view was still that the function of the lungs was to cool the blood. According to Galen, the heart had an innate warmth, with which organisms were born and which was the source of body warmth. DeleBoë changed the view based on his iatrochemical ideas, effervescence by the combination of acid and alkaline substances. Working on respiration, the student also had to study (frog) muscles and found that touching the nerve, even of a frog leg disconnected from the body, produced muscle contractions.

As there is no existing portrait of Swammerdam, the title page of his Historia Insectorum Generalis ofte Algemeene Verhandeling van de Bloedeloose Dierkens [General treatise of the bloodless animals] (1669) is shown here.

Like Stensen, he realized this was not in accordance with the idea of spirits being conducted by (hollow) nerves to the muscles. He observed similar phenomena while studying the diaphragm of living dogs. How could this be explained by material sent to the muscle from the brain so fast? Therefore, he devised an ingenious experiment with a muscle-nerve preparation in a glass tube, by which he was able to prove that no material was blown into the muscle upon contraction at all. His experiment stirred amazement, and several colleagues, including Stensen, visited his Leiden room, where he, Jan Swammerdam (1637-1680), as some of you may now have realized, demonstrated this and other experiments. Stensen told Bartholin about what he had seen in springtime of 1663.

Thomas Willis’ Cerebri Anatome (1664).

Clearly, Swammerdam and Stensen had a kindred spirit, both believing in their own critical insights to come to new knowledge, not merely accepting the ideas of previous generations. In this way, Stensen, experimenting with animals, found that the heart was a muscle and not an organ that produced heat.

Criticizing Willis and Descartes

Another subject Stensen wished to study was the anatomy and function of the brain. He experienced it was difficult to deduct its function from the anatomy. He reacted critically, when Thomas Willis’ (1621-1675) Cerebri Anatome was published (1664). Although it contained accurate anatomical plates (by Christopher Wren), and Willis described the well-known arterial circle (now known by the name circle of Willis) at the base of the brain, suggesting its function (“The joynings together of the Carotides, in most living Creatures, are made about the Basis of the Skull under the Dura Mater…”), Stensen was particular critical about his speculative discussion of the function of the brain.

Steno’s Discours sur l’anatomie du cerveau (published 350 years ago in 1669).

Both Descartes and Willis still adhered to the concept of spiritus animalis, being conducted by the ventricles and nerves, the first explaining it in a mechanical way (iatrophysical physiology), the second by chemical (iatrochemical physiology). He believed the little progress that had been made with respect to the knowledge of brain function was due to the fact that most physicians used the ancient doctrines as points of departure, rather than critically describing what was observed, although he realized that the methods available to study the brain were insufficient due to its soft structure.

These and other comments, Stensen presented in a lecture on the anatomy of the brain in Paris (1665, then 27 years old and already well-known), at wealthy amateur scientist and patron of many scientists Melchisédech Thévenot’s (1620-1692) group. It was published only in 1669 (350 years ago) with the title Discours sur l’anatomie du cerveau (à Messieurs de l’Assemblée de chez Monsieur Thevenot). He started the lecture in an unusual way: “Au lieu de vous promettre de contenter votre curiosité, touchant l’Anatomie du Cerveau; ie vous fais icy une confession sincere & publique, que ie n’y connois rien » [Instead of promising you to satisfy your curiosity, with respect to the brain; I here have to confess sincerely and in public that I do not know anything about it].

From Steno’s Discours (1669).

He ended the lecture by presenting suggestions how to continue research. The brain should be described accurately paying attention to all its aspects, including anatomy, embryology, comparative anatomy, function, etc. “Dans les animaux vivans, il y a a considerer toutes les choses que peuvent causer quelque alteration aux actions du cerveau, soit qu’elles viennent du dehors, comme les liqueurs, les blessures, les medicamens ; soit que les causes soient internes, commes les maladies, dont la medecine compte un grand nombre » [In living animals, one may consider all things that may cause any change to the actions of the brain, whether they may come from outside, as fluids, injuries, medicines; or be it internal causes, as diseases of which medicine counts a large number].

The publication was commented upon in the Transactions of the Royal Society (September 20, 1669) in which we find a three-page summary, containing the sentence “Next, he entertains the reader with an enumeration of the chief errors of anatomists touching the brain. And here he examins particularly the Systemes of dr. Willis and Monsieur Des Cartes.”

Stensen as well as Swammerdam were both sponsored by Thévenot, and the three worked together in 1665. Stensen moved to Florence in 1666, where he stayed with the Grand Duke of Tuscany, Ferdinando II) and his brother (Leopoldo de Medici), both interested in science, founding the Accademia del Cimento [Academy of Experiments] in 1657. Here, he published his Elementorum myologiae specimen, including detailed descriptions of the structure and contraction of muscles (1667). The work, however, was severely criticized by Mayow, Borelli, Bernoulli, and Boerhaave.

Section from the review of Steno’s Discours in Transactions of the Royal Society (September 20, 1669).

Interestingly, both Stensen and Swammerdam never practiced medicine. They made a religious turn in their lives. Although born in an orthodox Lutheran family, Stensen converted to Catholicism in 1667. Later, he became a priest and bishop in northern Germany. He died in Schwerin in 1686 (age 48). Swammerdam became depressive, possibly related to a long-lasting conflict with his father on providing means of sustaining life, but also by doubts about his future and a possible marriage. He became a member of the religious community of mystic Antoinette Bourignon (1616-1680). The last years of his life, he studied insects often using small microscopes that he made himself. He died in 1680 (age 43). His first biographer (Leiden professor Herman Boerhaave) published his Bybel der natuure of historie der insecten [Bible of nature or history of insects] in 1737, in which we find the experiments described above.

 

Literature

Kardel T. Steno. Life – Science – Philosophy. Acta Historica Scientiarum Naturalium et Medicinalium. 1994;42:1-159.

Kooijmans L. Gevaarlijke kennis. Inzicht en angst in de dagen van Jan Swammerdam. [Dangerous knowledge. Insight and fear in the days of Jan Swammerdam] Houten, Bohn, Stafleu Van Loghum, 2007

Stensen N. Discours sur l’anatomie du cerveau à Messieurs de l’Assemblée de chez Monsieur Thevenot. Paris, Robert de Ninville, 1669.

Swammerdam J. Bybel der natuure of historie der insecten [Bible of nature or history of insects]. Leiden, Severinus et al., 1736

WFN, AAN Present Invited Science Session on Infectious Disease

By John England, MD, FAAN, and Kiran Thakur

The American Academy of Neurology (AAN) held its 71st annual meeting in May in Philadelphia. During the meeting, the World Federation of Neurology (WFN) and the AAN co-sponsored a unique session on infectious disease and global health.

Left to right: John England, MD, FAAN, Kiran Thakur, MD, and Nischay Mishra, PHD. Photo courtesy of the American Academy of Neurology

The session was co-directed by John England, MD, FAAN, Richard M. Paddison professor of neurology and chair of the Department of Neurology at the Louisiana State University School of Medicine, and editor-in-chief of the Journal of the Neurological Sciences, and Kiran Thakur, the Winifred M. Pitkin assistant professor of neurology and neuroinfectious disease expert at Columbia University Irving Medical Center.

The session highlighted the joint efforts and partnership of the WFN and AAN to combat neurological diseases globally, and highlighted the work of world-renowned scientists on hot topics in infectious disease and global health. The session included presentations on the current acute encephalitis outbreaks (AES) in India, the acute flaccid myelitis (AFM) outbreaks in the United States and other global regions, the central nervous system (CNS) reservoir in HIV infection, and the newly recognized spectrum of post-infectious cases of autoimmune encephalitis.

The session’s first lecture was given by Prof. Manoj Murhekar, lead scientist and director of the National Institute of Epidemiology in Chennai, India, who spoke on acute encephalitis syndrome in Eastern Uttar Pradesh, India. His talk was followed by Dr. Nischay Mishra, a molecular biologist with expertise in advanced diagnostics and bioinformatics at the Center for Infection and Immunity at the Columbia University Irving Medical Center. He discussed molecular and serological discovery in CNS infectious diseases, highlighting his work identifying etiologies in AES outbreaks in India. Dr. Kevin Messacar and Dr. Kenneth Tyler (both at the University of Colorado School of Medicine), two major leaders of AFM investigations and members of the Center for Disease Control and Prevention (CDC) AFM taskforce, discussed features of enterovirus-associated AFM.

Audience at the invited science session. Photo courtesy of the American Academy of Neurology

Their presentations discussed human clinical features as well as an experimental mouse model, which was developed in Dr. Tyler’s laboratory. Dr. Serena Spudich, professor of neurology and division chief of infections and global neurology at Yale University School of Medicine, spoke on “Tapping into CNS reservoirs: single cell RNA sequencing of CSF in HIV.” She provided data on her recent studies using single-cell RNA sequencing, which identified a rare subset of myeloid cells that present a gene expression signature that significantly overlaps with neurodegenerative disease-associated microglia.

Prof. Josep Dalmau, director of the laboratory for the study of the pathogenesis of immune-mediated neuronal disorders at the University of Barcelona, Spain, and world authority on paraneoplastic disorders affecting the nervous system concluded the session with a lecture on viral triggers of autoimmune encephalitis. He highlighted his work in a multicenter prospective study showing that autoimmune encephalitis subsequently occurred in 27% of patients afflicted with herpes simplex encephalitis.

The session emphasized the importance of groundbreaking scientific work to combat neuroinfectious diseases globally and the importance of the WFN and AAN as organizations working together on global health initiatives. Further collaborative educational and scientific programs in infectious diseases, neuroscience, and world health will be presented at the upcoming World Congress of Neurology (WCN), which will be held Oct. 27-31 in Dubai, United Arab Emirates. •

World Congress of Neurology 2019 

As this issue of World Neurology is published, the excitement and tension surrounding the upcoming XXIV World Congress of Neurology (WCN) is building. All of those involved are readying their final preparations for what should be one of the most exciting, educationally informative, and varied gathering of speakers, attendees, and delegates from all over the world.

William Carroll, MD

Being a true World Congress of Neurology, it will have all the local flavor, international participation, and opportunity for collegial interaction that uniquely characterizes such meetings, setting it apart from the more regular annual regional meetings.

The Dubai WCN promises much. As a major travel hub, Dubai will reduce overall delegate travel time and offer a wide range of accessible quality accommodation and novel attractions. Most importantly, it has a first-class scientific and teaching program, guaranteed to be of interest to all.

The World Federation of Neurology (WFN) is most grateful to all those who have accepted the invitation to speak and to teach during this meeting. By accepting both roles, most of the invited speakers have aided the organizers and the WFN in substantially reducing the faculty costs, thus allowing more generous support in keeping with the recognition they deserve for their contribution. Furthermore, through reduced faculty costs and in partnership with the local Emirates Neurological Society, this WCN has been able to offer a record number of travel bursaries to assist the attendance of more than 200 young neurologists from low- and low-middle-income countries.

A further consequence of the modestly reduced faculty and the attempts of the program committees to engage more younger speakers (while also attaining topic, regional, and gender balance) is that some regular participants from past congresses may feel overlooked. To those who may feel this way, I would like to say that we have greatly appreciated their WCN contributions and in turn those to the WFN.

Other extraordinary highlights will include increasing the attractiveness of the Tournament of the Minds as described in my last column, the continuation of posters on poster boards rather than by e-format, the use of news conferences to disseminate important messages from the WCN, and upgraded social media. The decision to retain physical poster sessions is based on the observations at a number of other conferences of the relative sterility of e-poster sessions and the organic interactive environment seen at physical poster sessions. Delegate feedback here remains important.

There are three important press conferences planned. It is no coincidence that these will focus on the three largest contributors to the global disability adjusted life years. The first is the final activity for the successful 2019 World Brain Day – Migraine the Painful Truth. This press event will be co-hosted by the International Headache Society (IHS) and the WFN and will emphasize the impact that migraine has not only on the individual and on them as employees but also on their employers.

The second press conference will focus on the nexus between stroke and dementia, and the third on the recent alignment of the World Health Organization (WHO), WFN and the World Stroke Organization (WSO) through the change in categorization of stroke in ICD-11 from a circulatory disease to a brain disease and the implications of this.

Council of Delegates

The WCN also provides an important opportunity for groups to meet and discuss a wide range of issues related to neurology and neurology specialties. For the WFN, this is one of the most important times. The WFN Council of Delegates (COD), comprising representatives from most of the WFN national member organizations, meets Oct. 26 to conduct its business.

On this occasion, there are two trustee positions to be filled. These are the treasurer and an elected trustee. An important vote will also be held to determine the site of the 2023 WCN. More on these important matters will be discussed in the next issue of World Neurology.

A final, and arguably the most important meeting, will also occur during the WCN. This will be the Global Neurology Alliance (GNA). The alliance represents most of the topic specialties of neurology, such as the World Stroke Organization, Alzheimers International, the International League Against Epilepsy, the International Parkinson’s Disease and Movement Disorders Society, the Multiple Sclerosis International Federation, the International Headache Society, the International Federation of Clinical Neurophysiology, and the major associated organizations, such as the World Federation of Neurosurgical Societies, the World Federation of Neurorehabilitation, the International Brain Research Organization, the World Psychiatry Association, and the International Child Neurology Association.

Also included are the major regional neurology organizations, such as the American Academy of Neurology, the European Academy of Neurology, the African Academy of Neurology, the Pan American Federation of Neurological Societies, the Pan Arab Union of Neurological Societies, and the Asian and Oceanian Association of Neurology.

WFN Specialty groups, such as Amyotrophic Lateral Sclerosis and Motor Neurone Disease, Huntington’s Disease, Tropical and Infectious Neurology, Environmental Neurology, Migrant Neurology, Epidemiology, Functional Neurological Disorders, and others, are also included.

At present, the GNA does not include solely neuroscience or patient advocacy groups. The GNA represents what is arguably the most comprehensive advocacy group for all aspects of neurology. Topics likely to be considered are increasing the importance of brain health, the inequities of access to neurological care, and the burden of non-communicable neurological disease.

All up, the 2019 World Congress of Neurology promises to be a most memorable event. It is, as the Global Neurology Alliance illustrates, a celebration of all things neurological. I look forward to seeing you all in October. •